The effect of a flow-induces shear force on the molecular alignment in traditional bicelle mixtures characterized by 2H NMR (bibtex)
by John Kamendy
Abstract:
The "bicelle" is a model membrane system used for the study of compounds found in biological membrane systems. Bicelles are formed by the combination of the phospholipids DHPC and DMPC with water. At proper temperatures and molar ratios, these bicelle systems possess the characteristics of discotic nematic liquid crystals.
When subject to a magnetic field, bicelles have been shown to align themselves with their planar normal perpendicular to the field. It has also been shown that other compounds in the liquid crystalline phase will align themselves when subjected to an external shear force. This work focusses on the effect that a flow-induced shear force has on the alignment of the bicelle system, while also under the influence of a magnetic field. Theoretically, the two forces will compete with each other for control over the molecular orientation and a compromised alignment will result, at a slight angle from the original equilibrium position. In this new orientation, the bicelles should have more perfect alignment, and ideally, a uniaxial alignment will be achieved at the new equilibrium angle.
Deuterium NMR spectroscopy was used to characterize the alignment of these particles. In order to observe any effects of the shear force on the alignment, the spectra and relaxation times obtained from 2H NMR without the shear force will be compared with the spectra obtained when the sample experiences a shear force.
Reference:
John Kamendy, "The effect of a flow-induces shear force on the molecular alignment in traditional bicelle mixtures characterized by 2H NMR", 2002.
Bibtex Entry:
@bachelorsthesis{2002JK,
  title={The effect of a flow-induces shear force on the molecular alignment in traditional bicelle mixtures characterized by <sup>2</sup>H NMR},
  author={John Kamendy},
  month={April},
  year={2002},
  abstract={The ``bicelle" is a model membrane system used for the study of compounds found in
biological membrane systems. Bicelles are formed by the combination of the phospholipids
DHPC and DMPC with water. At proper temperatures and molar ratios, these bicelle
systems possess the characteristics of discotic nematic liquid crystals.<br>
When subject to a magnetic field, bicelles have been shown to align themselves with
their planar normal perpendicular to the field. It has also been shown that other
compounds in the liquid crystalline phase will align themselves when subjected to
an external shear force. This work focusses on the effect that a flow-induced shear
force has on the alignment of the bicelle system, while also under the influence of
a magnetic field. Theoretically, the two forces will compete with each other for
control over the molecular orientation and a compromised alignment will result, at a
slight angle from the original equilibrium position. In this new orientation, the
bicelles should have more perfect alignment, and ideally, a uniaxial alignment will
be achieved at the new equilibrium angle.<br>
Deuterium NMR spectroscopy was used to characterize the alignment of these particles.
In order to observe any effects of the shear force on the alignment, the spectra and
relaxation times obtained from <sup>2</sup>H NMR without the shear force will be
compared with the spectra obtained when the sample experiences a shear force.},
  note={Supervised by E. Sternin}
}
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