Publications
Main Teaching Research About
Brock University : Physics Department : Thad Harroun : Research  
Maple leaf with neutrons
2018
The equilibrium phase in heterogeneous Hertzian chains
Michelle Przedborski; Surajit Sen & Thad A. Harroun
Journal of Statistical Mechanics: Theory and Experiment
,
Vol. Accepted
,
2018
2017
Testing High Concentrations of Membrane Active Antibiotic Chlorhexidine Via Computational Titration and Calorimetry
B. Van Oosten; D. Marquardt & T. A. Harroun
Journal of Physical Chemistry B
,
Vol. 121
,
No. 18
,
pp. 4657-4668
,
2017
Fluctuations in Hertz chains at equilibrium
Michelle Przedborski; Surajit Sen & Thad A. Harroun
Physical Review E
,
Vol. 95
,
No. 032903
,
2017
Long-term behavior of Hertzian chains between fixed walls is really equilibrium
Michelle Przedborski; Surajit Sen & Thad A. Harroun
International Journal of Modern Physics B: Condensed Matter Physics, Statistical Physics, Applied Physics
,
Vol. 31
,
No. 10
,
pp. 1742011
,
2017
Neutron Scattering in Canada is at a Turning Point
Thad Harroun
Physics In Canada
,
Vol. 73
,
No. 1
,
2017
Opinion/Editorial
2016
A MARTINI extension for Pseudomonas Aeruginosa PAO1 lipopolysaccharide
Brad van Oosten & Thad A. Harroun
Journal of Molecular Graphics and Modelling
,
Vol. 63
,
pp. 125-133
,
2016
Vitamin E Circular Dichroism Studies: Insights to conformational changes induced by the solvent's polarity.
Drew Marquardt; Brad J. Van Oosten; Mikel Ghelfi; Jeffrey Atkinson & Thad A. Harroun
Membranes
,
Vol. 6
,
No. 4
,
pp. 56
,
2016
Cholesterol's Location in Lipid Bilayers
Drew Marquardt; Norbert Kuč erka; Stephen R. Wassall; Thad A. Harroun & John Katsaras
Chemistry and Physics of Lipids
,
Vol. 199
,
pp. 17 - 25
,
2016
Lipid Bilayer Thickness Determines Cholesterol’s Location in Model Membranes
Drew Marquardt; Frederick A. Heberle; Denise Greathouse; I. I. Roger E. Koeppe; Robert F. Standaert; Brad van Oosten; Thad A. Harroun; Jacob Kinnun; Justin Williams; Steve Wassall & John Katsaras
Soft Matter
,
Vol. 12
,
No. 47
,
pp. 9417-9428
,
2016
2015
Granular chains with soft boundaries: Slowing the transition to quasiequilibrium
Michelle Przedborski; Thad A. Harroun & Surajit Sen
Physical Review E
,
Vol. 91
,
No. 042207
,
pp. 1
,
2015
Localizing energy in granular materials
Michelle A. Przedborski; Thad A. Harroun & Surajit Sen
Applied Physics Letters
,
Vol. 107
,
(244105)
,
2015
α-Tocopherol’s Location in Membranes Is Not Affected by Their Composition
Drew Marquardt; Norbert Kucerka; John Katsaras & Thad A. Harroun
Langmuir
,
Vol. 31
,
No. 15
,
pp. 4464-4472
,
2015
Neutron Scattering at the Intersection of Heart Health Science and Biophysics
Drew Marquardt; Richard J. Alsop; Maikel C. Rheinstädter & Thad A. Harroun
Journal of Cardiovascular Development and Disease
,
Vol. 2
,
No. 2
,
pp. 125-140
,
2015
α-Tocopherol Is Well Designed to Protect Polyunsaturated Phospholipids: MD\ Simulations
Xiaoling Leng; Jacob J. Kinnun; Drew Marquardt; Mikel Ghefli; Norbert Kučerka; John Katsaras; Jeffrey Atkinson; Thad A. Harroun; Scott E. Feller & Stephen R. Wassall
Biophysical Journal
,
Vol. 109
,
No. 8
,
pp. 1608-1618
,
2015
Molecular Structures of Fluid Phosphatidylethanolamine Bilayers Obtained from Simulation-to-Experiment Comparisons and Experimental Scattering Density Profiles
Kuč Norbert erka; Brad Van Oosten; Jianjun Pan; Frederick Heberle; Thad Harroun & John Katsaras
The Journal of Physical Chemistry B
,
Vol. 119
,
No. 5
,
pp. 1947-1956
,
2015
Journal cover article.
Macrocyclic Oligoesters Incorporating a Cyclotetrasiloxane Ring
Mark Frampton; Drew Marquardt; Timothy Jones; Thad Harroun & Paul Zelisko
Biomacromolecules
,
Vol. 16
,
No. 7
,
pp. 2091-2100
,
2015
Aspirin inhibits formation of cholesterol rafts in fluid lipid membranes
Richard J. Alsop; Laura Toppozini; Drew Marquardt; Kuč Norbert erka; Thad A. Harroun; Rheinstä & Maikel C. dter
Biochimica et Biophysica Acta
,
Vol. 1848
,
No. 3
,
pp. 805-812
,
2015
2014
Small molecule interaction with lipid bilayers: A molecular dynamics study of chlorhexidine
Brad Van Oosten; Drew Marquardt; Komljenović Ivana ; Jeremy P. Bradshaw; Edward Sternin & Thad A. Harroun
Journal of Molecular Graphics and Modelling
,
Vol. 48
,
pp. 96-104
,
2014
Dimyristoyl Phosphatidylcholine: A Remarkable Exception to alpha-Tocopherol's Membrane Presence
Drew Marquardt; Justin A. Williams; Jacob J. Kinnun; Norbert Kucerka; Jeffrey Atkinson; Stephen R. Wassall; John Katsaras & Thad A. Harroun
Journal of the American Chemical Society
,
Vol. 136
,
No. 1
,
pp. 203-210
,
2014
Locations of Small Biomolecules in Model Membranes
Drew Marquardt & Thad A. Harroun
In: Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Technology
Norbert Kuč Mu-Ping Nieh erka, Georg Pabst & John Katsaras, Editors
Taylor and Francis,
2014
2013
Tocopherol Activity Correlates with Its Location in a Membrane: A New Perspective on the Antioxidant
Drew Marquardt; Justin A. Williams; Norbert Kuč erka; Jeffrey Atkinson; Stephen R. Wassall; John Katsaras & Thad A. Harroun
Journal of the American Chemical Society
,
Vol. 135
,
pp. 7523-7533
,
2013
The Observation of Highly Ordered Domains in Membranes with Cholesterol
Clare L. Armstrong; Drew Marquardt; Hannah Dies; Kuč Norbert erka; Zahra Yamani; Thad A. Harroun; John Katsaras; An-Chang Shi; Maikel C. Rheinstä & dter
PLOS One
,
Vol. 8
,
(e66162)
,
2013
2012
Synthesis of polyesters containing disiloxane subunits: Structural characterization, kinetics, and an examination of the thermal tolerance of Novozym-435
Mark B. Frampton; Jacqueline P. Sé guin; Drew Marquardt; Thad A. Harroun & Paul M. Zelisko
Journal of Molecular Catalysis B: Enzymatic
,
Vol. 85-86
,
pp. 149-155
,
2012
2011
Temperature Driven Annealing of Perforations in Bicellar Model Membranes
Mu-Ping Nieh; V. A. Raghunathan; Georg Pabst; Thad A. Harroun; Kazuomi Nagashima; Hannah Morales; John Katsaras & Peter Macdonald
Langmuir
,
Vol. 27
,
pp. 4838-4847
,
2011
2010
Cholesterol in unusual places
Norbert Kuč erka; Mu-ping Nieh; Drew Marquardt; Thad A. Harroun; S. R. Wassal & John Katsaras
Journal of Physics: Conference Series
,
Vol. 251
,
(012038)
,
2010
Cholesterol in Bilayers with PUFA Chains: Doping with DMPC or POPC Results in Sterol Reorientation and Membrane-Domain Formation
Norbert Kucerka; Drew Marquardt; Thad A. Harroun; Mu-Ping Nieh; Stephen R. Wassall; Djurre H. de Jong; Lars V. Schaefer; Siewert J. Marrink & John Katsaras
Biochemistry
,
Vol. 49
,
No. 35
,
pp. 7485-7493
,
2010
Location of Chlorhexidine in DMPC Model Membranes: A Neutron Diffraction Study
Ivana Komljenović Drew Marquardt; Thad A. Harroun & Edward Sternin
Chemistry and Physics of Lipids
,
2010
Canadians' health requires a secure source of medical isotopes
Thad Harroun & Dominic Ryan
Montreal Gazette
,
2010
February 22. Opinion/Editorial
Silence on the isotope report
Thad Harroun & Dominic Ryan
Winnipeg Free Press
,
2010
February 20. Opinion/Editorial
Neutron Diffraction and Vitamin E
Thad A. Harroun; Drew Marquardt; John Katsaras & Jeffrey Atkinson
Journal of Physics: Conference Series.
,
Vol. 251
,
(012039)
,
2010
The Location and Behavior of α-Tocopherol in Membranes
Jeffrey Atkinson; Thad Harroun; Stephen R. Wassall; William Stillwell & John Katsaras
Molecular Nutrition and Food Research
,
Vol. 54
,
pp. 641-651
,
2010
Special Issue: Widened Horizon of Vitamin E Research
2009
Submission to the Expert Review Panel on Medical Isotope Production: ``The Canadian Neutron Centre''
Dominic Ryan & Thad Harroun
2009
Nuclear inaction puts half-century of innovation at risk.
Anna Mehler Paperny
Globe and Mail
,
2009
June 20. News article
The Functional Significance of Lipid Diversity: Orientation of Cholesterol in Bilayers is Determined by Lipid Species.
Norbert Kuč erka; Drew Marquardt; Thad Harroun; Mu-Ping Nieh; Stephen Wassall & John Katsaras
Journal of the American Chemical Society
,
Vol. 131
,
No. 45
,
pp. 16358-16359
,
2009
Time to jump at opportunity
Gerry Klein
The Saskatoon StarPheonix
,
2009
July 16. Opinion/Editorial
Scattering for biophysics and biotechnology: Examples of self-assembled lipid systems
Thad A. Harroun; Norbert Kuč erka; Mu-Ping Nieh & John Katsaras
Soft Matter
,
Vol. 5
,
pp. 2694-2703
,
2009
Why the reactor shutdown is really bad news for neutron research
Thad Harroun
Globe and Mail
,
2009
July 15. Opinion/Editorial
Canada's medical isotope industry in peril as U.S. moves to make its own supply
Gloria Galloway & Karen Howlett
Globe and Mail
,
2009
July 10. News article
Making sense of the isotope shortage
Erik Dickson
Brock Press
,
2009
September 9. News article
2008
Ion distribution in multilayers of weak polyelectrolytes: A neutron reflectometry study
Oleh M. Tanchak; Kevin G. Yager; Helmut Fritzsche; Thad Harroun; John Katsaras & Christopher J. Barrett
The Journal of Chemical Physics
,
Vol. 129
,
(084901)
,
pp. 1-10
,
2008
Cholesterol Shows Preference for the Interior of Polyunsaturated Lipid Membranes
Siewert J. Marrink; Alex H. de Vries; Thad. A. Harroun; John Katsaras & Stephen R. Wassall
Journal of the American Chemical Society
,
Vol. 103
,
No. 1
,
pp. 10-11
,
2008
Effect of cations on the structure of bilayers formed by lipopolysaccharides isolated from P. Aeruginosa PAO1
Kuč Norbert erka; Erzsebet Papp-Szabo; Mu-Ping Nieh; Thad Harroun; Sarah Schooling; Jeremy Pencer; Eric Nicholson; Terry Beveridge & John Katsaras
The Journal of Physical Chemistry B
,
Vol. 112
,
pp. 8057-8062
,
2008
Cholesterol is found to reside in the center of a polyunsaturated lipid membrane
Thad Harroun; John Katsaras & Stephen Wassall
Biochemistry
,
Vol. 47
,
pp. 7090-7096
,
2008
Planning to 2050 for Materials Research with Neutron Beams in Canada
Greedan, J.; Adams, C.; Clapham, L.; Harroun, T. & Root, J.
Canadian Institute for Neutron Scattering
,
2008
2007
The study of liposomes, lamellae and membranes using neutrons and X-rays
Norbert Kuč erka; Mu-Ping Nieh; Jeremy Pencer; Thad Harroun & John Katsaras
Current Opinion in Colloid & Interface Science
,
Vol. 1
,
pp. 1
,
2007
Characterization of protein resistant, grafted methacrylate polymer layers bearing oligo(ethylene glycol) and phosphorylcholine side chains by neutron reflectometry
Wei Feng; Mu-Ping Nieh; Shiping Zhu; Thad A. Harroun; John Katsaras & John L. Brash
Biointerphases
,
Vol. 2
,
pp. 34-43
,
2007
2006
Water Distribution in Multilayers of Weak Polyelectrolytes
Oleh M. Tanchak; Kevin G. Yager; Helmut Fritzsche; Thad Harroun; John Katsaras & Christopher J. Barrett
Langmuir
,
Vol. 22
,
No. 11
,
pp. 5137-5143
,
2006
Neutron Scattering from Biomaterials in Complex Sample Environments
John Katsaras; Thad A. Harroun; Mu-Ping Nieh; Mukandan Chakrapani; M. J. Watson & V. A. Raghunathan
In: Neutron Scattering in Biology - Techniques and Applications
J. Fitter; T. Gutberlet & J. Katsaras, Editors
Springer,
Series: Biological and Medical Physics, Biomedical Engineering,
pp. 107-126
,
2006
Neutron Scattering for Biology
Thad A. Harroun; George D. Wignall & John Katsaras
In: Neutron Scattering in Biology - Techniques and Applications
J. Fitter; T. Gutberlet & J. Katsaras, Editors
Springer,
Series: Biological and Medical Physics, Biomedical Engineering,
pp. 1-18
,
2006
Cholesterol Hydrozyl Group Is Found To Reside in the Center of a Polyunsaturated Lipid Membrane
Thad A. Harroun; John Katsaras & Stephen R. Wassall
Biochemistry
,
Vol. 45
,
pp. 1227-1233
,
2006
0.9 T static magnetic field and temperature-controlled specimen environment for use with general-purpose optical microscopes
T. A. Harroun; C. M. Desrochers; M.-P. Nieh; M. J. Watson & J. Katsaras
Review of Scientific Instruments
,
Vol. 77
,
(014102)
,
pp. 1-4
,
2006
Autoinsertion of soluble oligomers of Alzheimer's Abeta(1-42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface
Richard H. Ashley; Thad A. Harroun; Thomas Hauss; Kieran C. Breen & Jeremy P. Bradshaw
BMC Structural Biology
,
Vol. 6
,
No. 21
,
pp. 1-11
,
2006
2005
Bilayer thickness and thermal response of dimyristoylphosphatidylcholine unilamellar vesicles containing cholesterol, ergosterol and lanosterol: A small-angle neutron scattering study
J. Pencer; M.-P. Nieh; T. A. Harroun; S. Krueger; C. Adams & J. Katsaras
Biochimica et Biophysica Acta
,
Vol. 1720
,
No. 1-2
,
pp. 84-91
,
2005
Spontaneously formed unilamellar vesicles with path-dependent size distribution
Mu-Ping Nieh; Velayudhan A. Raghunathan; Steve R. Kline; Thad A. Harroun; Chien-Yueh Huang; Jeremy Pencer & John Katsaras
Langmuir
,
Vol. 21
,
No. 15
,
pp. 6656-6661
,
2005
Structural Phase Behavior of High-Concentration, Alignable Biomemetic Bicellar Mixtures
M.-P. Nieh; V. A. Raghunathan; C. J. Glinka; T. A. Harroun & J. Katsaras
Macromolecular Symposia
,
Vol. 219
,
pp. 135-145
,
2005
``Bicellar'' Lipid Mixtures as used in Biochemical and Biophysical Studies
John Katsaras; Thad A. Harroun; Jeremy Pencer & Mu-Ping Nieh
Naturwissenschaften
,
Vol. 92
,
pp. 355-366
,
2005
A comprehensive examination of mesophases formed by DMPC and DHPC mixtures
Thad A. Harroun; Martin Koslowsky; Mu-Ping Nieh; Charles-Franç ois de Lannoy; V. A. Raghunathan & John Katsaras
Langmuir
,
Vol. 21
,
No. 12
,
pp. 5356 - 5361
,
2005
Variable temperature, relative humidity (0 - 100% RH), and liquid neutron reflectometry sample cell suitable for polymeric and biomimetic materials
Thad A. Harroun; Helmut Fritzsche; Mu-Ping Nieh; Kevin Yager; Oleh Tanchak; Christopher Barrett & John Katsaras
Review of Scientific Instruments
,
Vol. 76
,
No. 6
,
(065101)
,
pp. 1-5
,
2005
A structural study of the myristoylated N-terminus of ARF1
Thad A. Harroun; Jeremy P. Bradshaw; Kia Balali-Mood & John Katsaras
Biochimica et Biophysica Acta
,
Vol. 1668
,
No. 1
,
pp. 138-144
,
2005
Neutron Diffraction with an Excess-Water Cell
Thad A. Harroun; Kia Balali-Mood; Thomas Hauss; Toshiya Otomo & Jeremy P. Bradshaw
Journal of Biological Physics
,
Vol. 31
,
pp. 207-218
,
2005
Membrane-bound ARF1 peptide: Interpretation of neutron diffraction data by molecular dynamics simulation methods
K. Balali-Mood; T. A. Harroun & J. P. Bradshaw
Molecular Membrane Biology
,
Vol. 22
,
No. 5
,
pp. 379-388
,
2005
2004
Magnetically Alignable Phase of Phospholipid ``Bicelle'' Mixtures Is a Chiral Nematic Made Up of Wormlike Micelles
Mu-Ping Nieh; V. A. Raghunathan; Charles J. Glinka; Thad A. Harroun; Georg Pabst & John Katsaras
Langmuir
,
Vol. 20
,
No. 19
,
pp. 7893-7897
,
2004
Spontaneously Formed Monodisperse Biomimetic Unilamellar Vesicles: The Effect of Charge, Dilution and Time
M.-P. Nieh; T. A. Harroun; V. A. Raghunathan; C. J. Glinka & J. Katsaras
Biophysical Journal
,
Vol. 86
,
No. 4
,
pp. 2615-2629
,
2004
Neutron and X-ray Scattering From Biologically Relevant Materials
J. Katsaras; M.-P. Nieh; T. A. Harroun; M. Chakrapani & M. J. Watson
Physics in Canada
,
Vol. 60
,
No. 2
,
pp. 93-100
,
2004
Finite-Size Effects in Biomimetic Smectic Films
T. A. Harroun; V. A. Raghunathan; M.-P. Nieh & J. Katsaras
Physical Review E
,
Vol. 70
,
No. 6
,
(062902)
,
pp. 1-4
,
2004
The Relationship Between the Unbinding and Main Transition Temperatures of Phospholipid Bilayers Under Pressure
T. A. Harroun; M.-P. Nieh; M. J. Watson; V. A. Raghunathan; G. Pabst; M. R. Morrow & J. Katsaras
Physical Review E
,
Vol. 69
,
No. 3
,
(031906)
,
pp. 1-8
,
2004
Finite size effects do not reduce the repeat spacing of phospholipid multibilayer stacks on a rigid substrate
T. A. Harroun; M. Koslowsky; M.-P. Nieh; V. A. Raghunathan & J. Katsaras
European Physical Journal E
,
Vol. 13
,
No. 1
,
pp. 359-362
,
2004
2003
Neutron sample cell suitable for the diffraction of aligned biomaterials and capable of exerting up to 370 MPa of hydrostatic pressure
M. J. Watson; M.-P. Nieh; T. A. Harroun & J. Katsaras
Review of Scientific Intruments
,
Vol. 74
,
No. 5
,
pp. 2778-2781
,
2003
Concentration-Independent Spontaneously Forming Biomimetric Vesicles
M.-P. Nieh; T. A. Harroun; V. A. Raghunathan; C. J. Glinka & J. Katsaras
Physical Review Letters
,
Vol. 91
,
No. 10
,
(158105)
,
pp. 1-4
,
2003
The fusion peptide of simian immunodeficiency virus and the phase behaviour of N-methylated dioleoylphosphatidylethanolamine
Thad A. Harroun; Ian Gourlay; Kia Balali-Mood & Jeremy P. Bradshaw
Biochimica et Biophysica Acta
,
Vol. 1617
,
No. 1-2
,
pp. 62-68
,
2003
The membrane bound N-terminal domain of human adenosine diphosphate ribosylation factor-1 (ARF1)
Sarah M. A. Davies; Thad A. Harroun; Thomas Hauss; Sharon M. Kelly & Jeremy P. Bradshaw
FEBS Letters
,
Vol. 548
,
No. 1-3
,
pp. 119-124
,
2003
Molecular dynamics simulations of a mixed DOPC/DOPG bilayer
K. Balali-Mood; T. A. Harroun & J. P. Bradshaw
Euorpean Physical Journal E
,
Vol. 12
,
No. 1
,
pp. 135-140
,
2003
2002
The effect of fusion inhibitors on the phase behaviour of N-methylated dioleoylphosphatidylethanolamine
Malcolm J. M. Darkes; Thad A. Harroun; Sarah M. A. Davies & Jeremy P. Bradshaw
Biochimica et Biophysica Acta
,
Vol. 1561
,
No. 1
,
pp. 119-129
,
2002
2001
Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores
Lin Yang; Thad A. Harroun; Thomas M. Weiss; Lai Ding & Huey W. Huang
Biophysical Journal
,
Vol. 81
,
No. 3
,
pp. 1475-1485
,
2001
Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation
Thad A. Harroun; Jeremy P. Bradshaw & Richard H. Ashley
FEBS Letters
,
Vol. 507
,
No. 2
,
pp. 200-204
,
2001
2000
Membrane Thinning Effect of the β-Sheet Antimicrobial Protegrin
William T. Heller; Alan J. Waring; Robert I. Lehrer; Thad A. Harroun; Thomas M. Weiss; Lin Yang & Huey W. Huang
Biochemistry
,
Vol. 39
,
No. 1
,
pp. 139-145
,
2000
Oblique Membrane Insertion of Viral Fusion Peptide Probed by Neutron Diffraction
Jeremy P. Bradshaw; Malcolm J. M. Darkes; Thad A. Harroun; John Katsaras & Richard M. Epand
Biochemistry
,
Vol. 39
,
No. 22
,
pp. 6581-6585
,
2000
1999
Supramolecular Structures of Peptide Assemblies in Membranes by Neutron Off-Plane Scattering: Method of Analysis
Lin Yang; Thomas M. Weiss; Thad A. Harroun; William T. Heller & Huey W. Huang
Biophysical Journal
,
Vol. 77
,
No. 5
,
pp. 2648-2656
,
1999
Experimental Evidence for Hydrophobic Matching and Membrane-Mediated Interactions in Lipid Bilayers Containing Gramicidin
Thad A. Harroun; William T. Heller; Thomas M. Weiss; Lin Yang & Huey W. Huang
Biophysical Journal
,
Vol. 76
,
No. 2
,
pp. 937-945
,
1999
Theoretical Analysis of Hydrophobic Matching and Membrane-Mediated Interactions in Lipid Bilayers Containing Gramicidin
Thad A. Harroun; William T. Heller; Thomas M. Weiss; Lin Yang & Huey W. Huang
Biophysical Journal
,
Vol. 76
,
No. 6
,
pp. 3176-3185
,
1999
1998
Neutron Off-Plane Scattering of Aligned Membranes. I. Method of Measurement
Lin Yang; Thad A. Harroun; William T. Heller; Thomas M. Weiss & Huey W. Huang
Biophysical Journal
,
Vol. 75
,
No. 2
,
pp. 641-645
,
1998
1997
Effect of changing the size of lipid headgroup on peptide insertion into membranes
W. T. Heller; K. He; S. J. Ludtke; T. A. Harroun & H. W. Huang
Biophysical Journal
,
Vol. 73
,
No. 1
,
pp. 239-244
,
1997
1996
Membrane Pores Induced by Magainin
Steve J. Ludtke; Ke He; William T. Heller; Thad A. Harroun; Lin Yang & Huey W. Huang
Biochemistry
,
Vol. 35
,
No. 43
,
pp. 13723-13728
,
1996

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